Skin Complaints: links with Sub-optimal Skin Microbiome

Scientific Papers

The following is just a very small example of the latest skin microbiome research into the link between microbial diversity and common skin ailments and diseases.

Acne

The microbiota matters: In acne, it’s not us versus them

"Dysbiosis characterized by a lack of diversity is increasingly understood as a common theme in many skin disorders, and acne is no exception...."

By Kari Oakes
Dermatology News

Eczema

There is a strong association between worsening disease severity and lower skin bacterial diversity.

"Atopic dermatitis (AD) flares are characterized by low bacterial diversity...."

By Giuseppe Baviera et al
BioMed Research International

Dermatitis

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

"We report dramatic reductions in the skin microbial diversity during AD flares...."

By Heidi H. Kong et. al.
Genome Research

Rosacea

Twin Study Shows Change in the Facial Microbiome May Impact Rosacea

"Their results conformed with earlier studies that showed there was less bacterial diversity when skin disease was present..."

National Rosacea Society

Inflammation &
Autoimmune Disease

The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming

""The effects of biodiversity on immune health have implications for not only allergy and autoimmune disease, but many inflammatory NCDs, including mental health disorders"...."

By Susan L. Prescott et. al.
World Allergy Organization Journal

Psoriasis

Skin microbiome may differ in unique ways in psoriatic arthritis, psoriasis patients.

"The big overall message is there might be a decrease in microbiota diversity as you progress through the disease spectrum...."

By Damian McNamara
Dermatology News

Allergies

The microbiome in allergic disease: Current understanding and future opportunities

"Studies from Europe showing that living in a farming environment, which is linked to exposures to a diverse microbial community, is associated with a lower incidence of allergies."

By Yvonne J. Huang, et al.
The Journal of Allergy & Clinical Immunology

Ichthyosis

Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin

"our study reveals that FLG-deficient skin harbors significantly fewer bacterial taxa capable of using histidine as nutrient (carbon) source, ..."

By Patrick L.J.M. Zeeuwen, et al.
J ALLERGY CLIN IMMUNOL

Athlete's Foot & Ringworm (Tinea Pedis)

Human Skin Fungal Diversity

"New treatment strategies are required to strategically target microbial dysbiosis and to combat the increasingly observed resistance against our current arsenal of antimicrobials."

By Keisha Findley et al.
Nature

Wound Healing

The Wound Microbiome: Modern Approaches to Examining the Role of Microorganisms in Impaired Chronic Wound Healing

"Microorganisms are believed to play a significant role in impaired healing of chronic wounds and the development of infection-related complications.

By Ana M. Misic et al.
Advances in Wound Care

Blepharitis & Conjunctivitis

Human Microbiota and Ophthalmic Disease

"Disruption of the normal ocular surface microbiota may play a significant role as a cofactor in the pathogenesis of ophthalmic diseases, such as contact lens-associated corneal infiltrative events, blepharitis, and post-operative infectious endophthalmitis."

By Louise J. Lu and Ji Liu
Yale Journal of Biology & Medicine

Folliculitis & Pityriasis (Tinea) Versicolor

Healthy skin is actually cultivated by a well-balanced mix of bacteria and fungi (yeasts and molds).

"Malassezia yeasts are integral components of the skin microbiota, and therefore the therapeutic target should be controlling the Malassezia population rather than eradicating it..."

By Teun Boekhout
Fungal Biodiversity Center in Utrecht

Diabetic Skin

A longitudinal study of the diabetic skin and wound microbiome.

"The diabetic skin microbiome was significantly less diverse than control skin...."

By Melissa Gardiner et al.
PeerJ

Impetigo

Skin Microbiota in Contact Sports Athletes and Selection of Antiseptics for Professional Hygiene

"the presence of hemolytic forms of opportunistic bacteria in cutaneous microbiota, indicates dysbiotic changes and a decrease in the protective features of the host organism."

By Dilyara S. Martykanova, et al.
BioMed Research International

Skin Cancer

Bacteria on our bodies may be protecting us from skin cancer

"Your skin is crawling with bacteria – and some of them could be protecting you from cancer...."

By Jessica Hamzelou
New Scientist

Vitiligo

Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects

Our study reveals dysbiosis in the diversity of microbial community structure in lesional skin of vitiligo subjects.

By Parul Ganju, et al.
Scientific Reports

Guttate Psoriasis

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

"Staphylococcus spp. were mainly identified in patients with PV, while Streptococcus spp. were found in association with guttate psoriasis..."

By Maria J. E. Visser, et al.
Cell. Infect. Microbiol

Bullous Pemphigoid & Pemphigus

A distinct cutaneous microbiota profile in autoimmune bullous disease patients

"Emerging evidence suggests that host immunity may influence the skin microbiota, while the latter modulates cutaneous immunity..."

By Miodovnik M1, et al.
Experimental Dermatology

Dandruff

Dandruff Is Associated with Disequilibrium in the Proportion of the Major Bacterial and Fungal Populations Colonizing the Scalp

"Dandruff is linked to the balance between bacteria and fungi of the host scalp surface..."

By Cécile Clavaud, et al.
PLOS One

Leishmaniasis

The microbiological signature of human cutaneous leishmaniasis lesions exhibits restricted bacterial diversity compared to healthy skin

"These findings demonstrate that traditional evaluation by culturing pathogenic bacteria is highly biased...."

By Salgado, et al.
Memórias do Instituto Oswaldo Cruz

Sunburn

The skin microbiome and immune system: Potential target for chemoprevention?

"A recent study demonstrated that the skin microbiome of cachectic cancer patients is less diverse than that of healthy participants"

By Mohammad Asif Sherwani et al.
Photodermatology, Photoimmunology & Photomedicine

Herpes (Cold Sores etc)

Patients with AD have long been known to have increased susceptibility to S. aureus and virus infection such as herpes.

"A strong association between lower skin microbiome diversity and increased disease severity was demonstrated. ..."

By Susan Prescott
RESEARCH REVIEW™ .

Hidradenitis Suppurativa

In nonlesional skin from patients with HS, we found a significantly increased diversity of the microbiota compared with HS lesional skin

"This finding lends credence to a hypothesis of an imbalanced skin microbiome preceding the development of HS lesions..."

By Hans Christian Ring,, et al.
JAMA Dermatol.

Inflammatory peeling skin disease

Significantly reduced diversity and altered composition of the skin microbiome in peeling skin disease

"The subject affected by PSD showed a decreased diversity and genera richness...."

By G. Perazzolli,, et al.
46th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung .

Pruritus

Is itch intensity in atopic dermatitis associated with skin colonization by staphylococcus aureus?.

"It may be hypothesized that restoring the natural composition of the skin microbiome may reduce pruritus intensity."

By Leszek Blicharz, et al.
Indian Journal of Dermatology, Vol 65, P. 17-21.

Allergic Rhinitis

Nasal microbiome under natural pollen exposure conditions.

"individual nasal microbiome of non‐allergic subjects did not change during or outside of the birch pollen season, whereas the alpha diversity of samples from AR patients decreased during the pollen season...."

By D. Rauer, et al.
Chair and Institute of Environmental Medicine, UNIKA‐T, 86156 Augsburg, Germany;.

Sensitive Skin

Analysis of the Bacterial Flora of Sensitive Facial Skin Among Women in Guangzhou

"Sensitive skin is accompanied by a decrease in species diversity and richness, which may be relevant to the weakening of the microbial barrier..."

By Qiao Z,, et al.
Institute of Biomedicine and Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University.

Darier's Disease

Darier’s disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour .

"We identified a disease-specific cutaneous microbiome with a loss of microbial diversity and of potentially beneficial commensals."

By Yacine Amar, et al.
Microbiome, Vol 11, 162(2023).